(1) Unraveling the mysteries of the non-canonical translatome
Systematic identification, characterization, and functional analysis of non-canonical open reading frames, including uORFs, dORFs, lncORFs, circORFs and others.

(2) Exploring the landscape of cryptic neoantigens and their applications
Developing efficient approaches to identify and characterize immunogenic neoantigens, and unlocking the source of cryptic neoantigens through translation of non-canonical ORFs.

Selected publications

(‡ indicates (co-) first author, § indicates (co-)corresponding author )

1. Wang Y^‡, Tang YW^‡, Xie Z^§, Wang HW^§. RPFdb v3.0: An Enhanced Repository for Ribosome Profiling Data and Related Content. Nucleic Acids Research. 2025;53(D1):D293–D298.
2. Yang LD^‡, Yi L^‡, Yang JQ, Zhang R, Xie Z^§, Wang HW^§. Temporal landscape and translational regulation of A-to-I RNA editing in mouse retina development. BMC Biology. 2024;22(1):106.
3. Xie MZ^‡, Yang LD^‡, Chen GN^‡, Wang Y, Xie Z^§, Wang HW^§. RiboChat: a chat-style web interface for analysis and annotation of ribosome profiling data. Briefings in Bioinformatics. 2022;23(2):bbab559.
4. Li HH^‡, Xie MZ^‡, Yan Wang^‡, Yang LD, Xie Z^§, Wang HW^§. riboCIRC: a comprehensive database of translatable circRNAs. Genome Biology. 2021;22(1):79.
5. Chen KN^‡, Chen CY^‡, Li HH, Yang JQ, Xiang MQ, Wang HW^§, Xie Z^§. Widespread translational control regulates retinal development in mouse. Nucleic Acids Res. 2021;49(17):9648-9664.
6. Wang HW^‡,§, Yan Wang^‡, Yang JQ^‡, Zhao Q^‡, Tang N, Chen CY, Li HH, Cheng CC, Xie MZ, Xie Z^§. Tissue-and stage-specific landscape of the mouse translatome. Nucleic Acids Res. 2021;49(11):6165-6180.
7. Wang HW^‡,§, Yan Wang^‡, Xie SQ, Liu YZ, Xie Z^§. Global and cell-type specific properties of lincRNAs with ribosome occupancy. Nucleic Acids Res. 2017;45(5):2786-2796.